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methylisothiazolinone

CAS
2682-20-4
CosIng ID
35341
Functions
Preservative

Regions

MarketStatusLimitRuleSource
European UnionRestricted≤ 0.0015%Annex V, entry 39 (rinse-off only, ≤0.0015%); banned leave-onSource
United StatesNo entry in our compiled ruleset — verify with FDA — FD&C Act + MoCRA.
South KoreaNo entry in our compiled ruleset — verify with MFDS — Cosmetics Act ingredient standards.
JapanNo entry in our compiled ruleset — verify with MHLW — Standards for Cosmetics.
ChinaNo entry in our compiled ruleset — verify with NMPA — Safety and Technical Standards for Cosmetics.
United KingdomNo entry in our compiled ruleset — verify with OPSS — UK Cosmetics Regulation.
CanadaNo entry in our compiled ruleset — verify with Health Canada — Cosmetic Ingredient Hotlist.
AustraliaNo entry in our compiled ruleset — verify with AICIS / TGA.
IndiaNo entry in our compiled ruleset — verify with CDSCO / BIS — IS 4707.
BrazilNo entry in our compiled ruleset — verify with ANVISA — RDC resolutions.
MexicoNo entry in our compiled ruleset — verify with COFEPRIS.
ASEANNo entry in our compiled ruleset — verify with ASEAN Cosmetic Directive — Annexes.
California (US)No entry in our compiled ruleset — verify with OEHHA Prop 65 · AB-2771 (PFAS).
Washington State (US)No entry in our compiled ruleset — verify with Toxic-Free Cosmetics Act (HB 1047).

Retailer standards

RetailerStatusNoteSource
Clean at SephoraBannedProhibited under Sephora CleanSource
Conscious Beauty at UltaNo entry in our compiled ruleset — verify with Ulta Beauty made-without list.
Target CleanNo entry in our compiled ruleset — verify with Target Clean icon ingredient criteria.
Amazon listing complianceBannedSensitizer — prohibited under Amazon AwareSource
Credo Clean StandardNo entry in our compiled ruleset — verify with The Credo Clean Standard dirty list.
Whole Foods Body CareBannedListed "unacceptable"; function: preservative (MI). Confirmed verbatim in source PDF table.Source
Whole Foods Premium Body CareNo entry in our compiled ruleset — verify with Whole Foods Market premium body-care standards.
Walmart Sustainable ChemistryNo entry in our compiled ruleset — verify with Walmart sustainable chemistry commitment.
Walmart Made Without ListNo entry in our compiled ruleset — verify with Walmart made-without-list substances.
CVS store-brand chemicals policyRestrictedMI alone capped at 100 ppm (0.01%) in leave-on or rinse-off products; cannot be combined with MCI in leave-on products (CAS 2682-20-4) — exact ppm limit verbatim-matched in sourceSource
Costco vendor complianceNo entry in our compiled ruleset — verify with Costco wholesale vendor requirements.
Douglas clean criteriaNo entry in our compiled ruleset — verify with Douglas (EU) clean beauty criteria.
The Detox Market banned listBannedOn The Detox Market's published banned-ingredients list. Stated concern: Organ Toxicity/Irritation, Allergen, Neurotoxicity. Products stocked by The Detox Market are formulated without it.Source

2026-07-21 · Compiled from cited primary sources. Informational only — not legal advice.

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